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Melatonin controlled release caplet quick guide to effects –part 2

Views: 0     Author: Site Editor     Publish Time: 2022-07-06      Origin: Site

When to take melatonin controlled release caplet (dose)?

If you want to try melatonin, it is best to start with a low dose.

For example, take 0.5 mg/mg (500 mcg) or 1 mg 30 minutes before bedtime.

If this dose doesn't help you fall asleep, try increasing it to 3 to 5 mg.

But taking more melatonin may not help you fall asleep faster; the goal is to find the lowest dose that will put you to sleep.

Delayed release melatonin effects

1. Help to fall asleep and assist sleep

One third of a person's life is spent in sleep, if long-term insomnia will lead to numerous diseases (including immune disorders, cardiovascular disease, cognitive disorders, etc.), and even the aging rate is two to three times faster than normal people. Recently, the scientific community has also discovered that sleep is an important time for the brain to clear neurotoxins, for example, the beta-amyloid protein associated with Alzheimer's disease is flushed out by the cerebrospinal fluid during sleep. In other words, chronic insomnia will significantly increase the incidence of neurodegenerative dementia.

In a large analysis (integrating 15 clinical studies of unmedicated insomniacs), melatonin (1 to 2 hours before bedtime) was found to significantly reduce the time required to fall asleep, and to improve sleep efficiency and increase sleep duration in insomniacs.

Other studies have also found that the effect of melatonin in helping to fall asleep and regulating the physiological clock may be related to its ability to lower the body's core body temperature (a lower core body temperature before bedtime helps to induce sleepiness and to enter deep sleep more quickly).

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2. Improve non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is triggered by the accumulation of fat in liver cells and is associated with diabetes, dyslipidemia, obesity, cardiovascular disease, and metabolic syndrome, and poor control may lead to cirrhosis, liver failure, and hepatocellular carcinoma.

In Western countries, where approximately 30% of adults have NAFLD, the first-line treatment is lifestyle interventions, including diet, exercise, and weight loss. Of these, weight loss is key, but only a minority of patients are able to reach the target threshold.

Melatonin supplementation (daily dose of 6 to 18 mg over the trial period between 4 and 56 weeks) helps to reduce aspartate aminolevulinic acidase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT).

3. Regulate blood pressure

Blood pressure (Blood pressure) is defined as the pressure of blood circulation on the walls of blood vessels, and the body is able to regulate blood pressure as needed, so it is normal for blood pressure readings to vary. Chronic high blood pressure increases the likelihood of cardiovascular disease and leads to organ damage. Possible long-term effects include: poor circulation in the legs, heart failure, stroke, kidney failure, etc.

Oral melatonin has the effect of lowering Systolic Blood Pressure (- 3.43 mm Hg) and Diastolic Blood Pressure (- 3.33 mm Hg).

4. Relieve fibromyalgia

Fibromyalgia syndrome (FMS) is a chronic condition (estimated prevalence 0.5% to 5.8%) characterized by generalized pain, fatigue, sleep disturbances, cognitive impairment, and anxiety of unknown etiology that can coexist with hypothyroidism and chronic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. And underlying pathophysiological factors include biological and genetic influences, environmental triggers, and abnormal neuroendocrine and autonomic nervous system function.

A systematic review of the literature suggests that melatonin administration may help improve disease effects, sleep quality, pain levels, and pain point counts.

5. Regualte blood lipids

Dyslipidemia is a disorder of lipid metabolism that results in abnormal levels of lipids in the blood and is a major risk factor for cardiovascular disease, stroke and type 2 diabetes.

Studies have shown that a 10 mg/dL increase in total cholesterol is associated with a 5% and 9% increase in total and cardiovascular mortality, respectively

A systematic literature review and pooled analysis showed that melatonin improved LDL cholesterol (SMD: -0.31 mmol/L) and triglyceride levels (SMD: -0.45 mmol/L) compared to controls.

6. Control blood sugar

Common symptoms of hyperglycemia include polyuria, polydipsia, weight loss, sometimes accompanied by polyphagia and blurred vision. Long-term complications include retinopathy, nephropathy, foot ulcers, amputations, and autonomic neuropathy causing gastrointestinal, genitourinary, cardiovascular symptoms and sexual dysfunction.

Melatonin supplementation (daily doses between 3 mg and 10 mg) reduces fasting glucose and improves the Quantitative Insulin Sensitivity Index (QUICKI), but does not significantly improve insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR), or glycated hemoglobin levels.

7. Adjuvant cancer therapy

Cancer is a disease in which the uncontrolled proliferation of cells in an organism leads to the invasive decline of normal cells or tissues.

Current cancer treatment is based on radiation therapy, chemotherapy and surgery. Radiotherapy and chemotherapy inhibit the proliferation of cancer cells by damaging DNA. However, DNA damage can interfere with normal cells throughout the body and is associated with many side effects.

A meta-analysis (20 randomized controlled trials) of the literature suggests that the use of melatonin in combination with cancer treatments (including chemotherapy, molecular target therapy, radiotherapy and supportive care) can further improve tumor remission and overall survival rates.