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Melatonin's various effects

Views: 0     Author: Site Editor     Publish Time: 2022-02-28      Origin: Site

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Sleep problems have been with us for a long time. More than 2,000 people conducted in April 2021 according to a survey (PDF), 56% of Americans stated that their sleep disorders have increased since the beginning of the COVID-19 pandemic. The most common is that they report difficulty falling asleep or falling asleep. According to a nationally representative Consumer Reports survey of 1,767 adults,in 2018,80% of American adults said they had insomnia at least once a week.

In search of relief, many people turn to dietary supplements. According to AASM data, more than half of Americans said they had used supplements, drugs or other substances to help them fall asleep, and 68% of them said they used sleep aids more frequently than before.

So far, the most popular sleep supplement is melatonin, which is a hormone naturally produced by the body that controls our sleep-wake cycle. According to the Nutrition Business Journal, the sales of melatonin in 2020 increased by 42.5% to US$687 million.

Melatonin is a hormone secreted by the pineal gland of the brain, usually at night. It regulates the body's circadian rhythm, and the approximately 24 hour internal "clock" helps control when you are sleepy and when you feel awake.

It is the "dark hormone," Czeisler said. The brain should start releasing this hormone when it's dark, usually a few hours before we go to bed. Taking a synthetic supplement of this hormone may help people who cannot naturally produce this hormone due to age, one of several health disorders, or because they try to go to bed at a different time than usual.

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It’s controlled-release plus extended-release tablet which has a core containing 7.5mg of melatonin and Vitamin B6 wrapped with a extended-release coating. The controlled-release coating is coated with 2.5 mg of melatonin,the outer layer is a protective layer.2.5 mg of melatonin is released quickly after the melatonin is swallowed, and the concentration in the blood is increased rapidly,so people will feel drowsiness. The 7.5 mg of melatonin in the tablet core will be released at a constant rate for 5 to 8 hours, continuously maintaining the concentration in the blood, allowing you to maintain a good deep sleep until dawn.

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Insomnia

Studies have shown that melatonin supplements can help people with circadian rhythm disorders (such as those with jet lag or night shifts) and people with low melatonin levels (such as some elderly people and schizophrenia) sleep better. A review of the scientific literature suggests that melatonin supplements may help prevent jet lag, especially for people who span 5 or more time zones.

Some clinical studies have shown that when melatonin is taken for a short period of time (a few days to a few weeks), melatonin is more effective than placebo in reducing the time to fall asleep, increasing sleep time and improving daytime alertness.

Heart disease

A number of studies have shown that melatonin has cardioprotective effects, including antioxidant and anti-inflammatory effects. Studies have also shown that melatonin may help lower blood pressure levels and improve cholesterol levels.

Menopause

Melatonin supplements can improve sleep problems associated with menopause. Other research suggests that it may help restore quality of life and prevent bone loss in perimenopausal women. However, it does not seem to relieve other symptoms of menopause.

Benzodiazepine withdrawal

Some studies indicate that melatonin may help older people who are gradually reducing or stopping the use of benzodiazepines such as diazepam (Valium), alprazolam (Xanax) or lorazepam (Ativan) ). Taking a Timed Releasing Melatonin 10 mg 60 Tablets With Private Brands can improve the sleep quality of people who stop using benzodiazepines. Unless under the strict supervision of a healthcare provider, you should not use melatonin in combination with sedative drugs.

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Breast cancer

Several studies have shown that low melatonin levels may be related to the risk of breast cancer. For example, women with breast cancer tend to have lower levels of melatonin than women without breast cancer. Laboratory experiments have found that low levels of melatonin stimulate the growth of certain types of breast cancer cells, and adding melatonin to these cells slows their growth. Preliminary evidence also suggests that melatonin may enhance the effects of some chemotherapy drugs used to treat breast cancer. In a study involving a small number of women with breast cancer, melatonin (taken 7 days before starting chemotherapy) prevented the reduction of platelets in the blood. This is a common complication of chemotherapy and can lead to bleeding.

In another small study of women who took tamoxifen for breast cancer but did not see improvement, the addition of melatonin resulted in a modest reduction in tumors in more than 28% of women. Women with breast cancer should consult their doctor before taking melatonin.

Prostate cancer

Studies have shown that men with prostate cancer have lower levels of melatonin than men without prostate cancer. In test-tube studies, melatonin prevents the growth of prostate cancer cells. In a small study, melatonin combined with conventional medications improved the survival rate of 9 out of 14 men with metastatic prostate cancer. More research is needed before doctors can make recommendations in this area. Men with prostate cancer should consult their doctor before taking the medicine.

Attention deficit hyperactivity disorder (ADHD) and autism

Some evidence suggests that melatonin may help promote sleep in children with ADHD or autism, although it does not seem to improve the behavioral symptoms of ADHD or autism.

Fibromyalgia and chronic pain

A randomized, placebo-controlled study found that patients with fibromyalgia experienced significant reduction in symptoms when taking melatonin supplements alone or in combination with fluoxetine (Prozac). Other research suggests that melatonin may play a role in other pain conditions, such as migraines. People with chronic pain should consult their doctor before using melatonin because it can interact with certain medications.